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New Study -MC1R stimulation by Alpha-MSH (Read 1877 times)
RIURAO
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New Study -MC1R stimulation by Alpha-MSH
06/10/10 at 10:02:31
 
Very interesting new study wich also confirm some theories wich suggest that melanotan-1 could prevent Skin Cancer and Melanoma:
 
 
Quoted from http://www.ncbi.nlm.nih.gov/pubmed/20067588
 
 
MC1R stimulation by alpha-MSH induces catalase and promotes its re-distribution to the cell periphery and dendrites.
Maresca V, Flori E, Bellei B, Aspite N, Kovacs D, Picardo M.
 
Laboratorio di Fisiopatologia Cutanea e Biologia Molecolare-Centro di Metabolomica, San Gallicano Dermatologic Institute IRCCS, Rome, Italy.
 
Abstract
We demonstrated a direct correlation between melanogenic and catalase activities on in vitro and ex vivo models. Here, we investigated whether the stimulation of Melanocortin-1 Receptor (MC1R) could influence catalase expression, activity and cellular localization. For this purpose, we treated B16-F0 melanoma cells with alpha-Melanocyte Stimulating Hormone (alpha-MSH) and we showed a rapid induction of catalase through a cAMP/PKA-dependent, microphthalmia-associated transcription factor (MITF) independent mechanism, acting at post-transcriptional level. Moreover, alpha-MSH promoted a partial re-distribution of catalase to the cell periphery and dendrites. This work strengthens the correlation between melanogenesis and anti-oxidants, demonstrating the induction of catalase in response to a melanogenic stimulation, such as alpha-MSH-dependent MC1R activation. Moreover, this study highlights catalase regulatory mechanisms poorly known, and attributes to alpha-MSH a protective role in defending melanocytes, and possibly keratinocytes, not only on the basis of its pigmentary action, but also for its capacity to stimulate a quick anti-oxidant defence.
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Re: New Study -MC1R stimulation by Alpha-MSH
Reply #1 - 07/17/11 at 10:44:40
 
It could possibly do so by inducing melanogenesis which will in turn help prevent damage from UV rays. The melanogenesis itself does not protect against skin cancer, the growth induction might actually boost skin cancer. Who knows.
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Re: New Study -MC1R stimulation by Alpha-MSH
Reply #2 - 07/17/11 at 16:31:52
 
At least not in vitro as shown in some experiments with alpha- msh an diffenret  of the most common melanoma cultives
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Re: New Study -MC1R stimulation by Alpha-MSH
Reply #3 - 07/20/11 at 08:41:53
 
Maybe so, but I doubt in vitro studies have any proving power in this sense.  
 
edit- Even so, keep up the good work!
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Re: New Study -MC1R stimulation by Alpha-MSH
Reply #4 - 07/21/11 at 13:42:17
 
Well, The in-vivo study is in this forum..... I believe it is a good prove, donīt you?
 
I understand you, and I would like to investigate more or have more studies regarding this Alpha msh but at least what we have nothing points to danger regarding Melanoma.
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Re: New Study -MC1R stimulation by Alpha-MSH
Reply #5 - 08/04/11 at 07:23:08
 
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