Bremelanotide related news:
On August 12, Palatin announced successful results of a phase I clinical trial of subcutaneously administered bremelanotide for male erectile dysfunction:
http://www.palatin.com/news/news.asp?param=221 Salient points from their announcement: none of the previous blood pressure issues that presented during the nasal clinical trials appeared in this trial. They attribute this to better control of dosing via subcutaneous administration. According to what they report, it was apparently the case that nasal dosing could not deliver a consistent amount of the drug across all members of the previous cohorts and some participants may have received too much of the drug due to physiological variations in their nasal passages that allowed for a more efficacious delivery of the drug than for others.
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The September issue of
Men's Journal has an article about bremelanotide wherein the author describes his positive experience in using the drug via snorting 10mg of it in powdered form.
Men's Journal magazine [USA] (September 2009, online version published Aug. 26, 2009):
The Libido Drug The article covers the development of the black market for the drug (even mentioning the source the author used, a source familiar to these forums) and includes details from work done with the drug by the Concordia University researcher Jim Pfaus
Ph.D. Pfaus was one of the original researchers testing the drug on rats. Pfaus gives a cautionary view relative to usage of it outside of FDA approval. Also included is an opinion of the drug from a known critic of the development of drugs for female sexual dysfunction, psychologist Leonore Tiefer
Ph.D who starts off by saying, “It’s baloney”.
There are some errors in the article including the following from the history of its development:
Quote:Originally developed as a self-tanning agent, the drug had been repurposed when male study subjects reported a surprising side effect: erections. A New Jersey pharmaceutical company called Palatin Technologies had bought the drug, then turned the pill into a powder that could be delivered nasally...
referencing bremelanotide's progenitor drug melanotan II (which has the same erectile/libido effects) which never came in pill form.
Winning lines from the article:
Quote:Then, at four in the morning, it took hold. I felt a great surge of affection (greater than any regular level of arousal) for my lovely wife. My body tingled and, yes, I developed an erection that wouldn’t quit.
-Scott