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no side effects? (Read 4451 times)
pumpkin069
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no side effects?
12/19/08 at 23:13:07
 
Hey guys, just started my first melanotan-1 cycle and except for sharp stinging pain during injection (insulin needle into abb fat) i'm experiencing no side effects..
 
this is what i've done so far;
 
Day 1 - 0.5mg
Day 2 - 1.0mg
Day 3 - 1.0mg
 
am i just lucky? or is this stuff really melanotan..
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Re: no side effects?
Reply #1 - 12/20/08 at 11:40:33
 
Did you buy it in powder form?
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Re: no side effects?
Reply #2 - 12/21/08 at 00:47:44
 
yep, bought 5 10mg vials which came in powder form, mixed one with 200 units of bac water and currently using that
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Re: no side effects?
Reply #3 - 12/21/08 at 01:16:32
 
Depending upon your weight those are likely low doses for melanotan-1. What you can do is determine what your personal tolerance is for melanotan-1 by gradually increasing your dosage until you establish a dosing level that gives you an undesirable side effect. From that level of dosage you would go back to the last lower dosage that didn't cause this undesirable effect. This is how the original researchers came to establish dosing on the original research subjects.  Such a level of dosing should give you the maximum tanning capability of the peptide while not having your body waste any excess.  
To know what your level of dosing is relative to what an "average" might be know that in the original clinical dose-ranging study the researchers established an average dosage for skin type III-IV males of 0.16 mg of melanotan-1 per Kg of body weight per day. So depending upon your gender and skin type your own personal dosing level should be somewhere in that neighborhood (or a bit more if you are a low skin type). If you're not noticing some sort of a side effect around this average dosage then there's a possibility that there is something wrong with what you are using.
 
-Scott
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Re: no side effects?
Reply #4 - 12/21/08 at 10:55:50
 
Quote from Scott on 12/21/08 at 01:16:32:
To know what your level of dosing is relative to what an "average" might be know that in the original clinical dose-ranging study the researchers established an average dosage for skin type III-IV males of 0.16 mg of melanotan-1 per Kg of body weight per day.
-Scott

 
This is serious?! 0.16mg*70kg=11.2mg of melanotan-1 per day?!??? it sounds crazy. I didn't see someone in the logs who is using so much melanotan-1 per day (and I don't talk about how much expensive is to use so much melanotan per day).
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Re: no side effects?
Reply #5 - 12/21/08 at 19:06:23
 
Quote from Nargilyos on 12/21/08 at 10:55:50:
This is serious?! 0.16mg*70kg=11.2mg of melanotan-1 per day?!??? it sounds crazy. I didn't see someone in the logs who is using so much melanotan-1 per day (and I don't talk about how much expensive is to use so much melanotan per day).

Yes, according to the studies on melanotan-1, this is the level of dosing found to be optimal on average (at least for skin type III-IV males) for test subjects administered via subcutaneous injections. This dosage level was duplicated by Ross Barnetson et al in 2003 with reported tanning successes for lower skin types administered melanotan-1 daily over a three month period. This difference in quantity of peptide per dose is a big part of the reason that melanotan II has caught on so much more than melanotan-1. It takes roughly a tenth of the amount of peptide to equate to the reported optimal dose and therefore is much more cost effective. Do know though that the implant version of melanotan-1 was found to be much more effective such that much less of the peptide is needed to have the same effect.
 
-Scott
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Re: no side effects?
Reply #6 - 12/21/08 at 21:30:38
 
Pumpkin, where did you buy your melanotan from?
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Re: no side effects?
Reply #7 - 12/22/08 at 11:54:54
 
Quote from Scott on 12/21/08 at 19:06:23:
Quote from Nargilyos on 12/21/08 at 10:55:50:
This is serious?! 0.16mg*70kg=11.2mg of melanotan-1 per day?!??? it sounds crazy. I didn't see someone in the logs who is using so much melanotan-1 per day (and I don't talk about how much expensive is to use so much melanotan per day).

Yes, according to the studies on melanotan-1, this is the level of dosing found to be optimal on average (at least for skin type III-IV males) for test subjects administered via subcutaneous injections. This dosage level was duplicated by Ross Barnetson et al in 2003 with reported tanning successes for lower skin types administered melanotan-1 daily over a three month period. This difference in quantity of peptide per dose is a big part of the reason that melanotan II has caught on so much more than melanotan-1. It takes roughly a tenth of the amount of peptide to equate to the reported optimal dose and therefore is much more cost effective. Do know though that the implant version of melanotan-1 was found to be much more effective such that much less of the peptide is needed to have the same effect.

-Scott

 
Thank you Scott.
So will it be unnecessary for me to try melanotan-1 with low doses (about 1-1.5 mg per day)? with my skin type- "1+" I don't know what noticeable results I will see. What is interesting is that nobody in the logs really did such a hige doses...
  I didn't think about melanotan-1 until I got some problems with melanotan II. Now I really don't know what to do...
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Re: no side effects?
Reply #8 - 12/22/08 at 14:37:23
 
Quote from Nargilyos on 12/22/08 at 11:54:54:
Thank you Scott.
So will it be unnecessary for me to try melanotan-1 with low doses (about 1-1.5 mg per day)? with my skin type- "1+" I don't know what noticeable results I will see. What is interesting is that nobody in the logs really did such a hige doses...
 I didn't think about melanotan-1 until I got some problems with melanotan II. Now I really don't know what to do...

 
Yes, you are right about the dosages in the melanotan-1 logs being a bit low. This is likely a part of the reason that folks have not seen equivalent results compared to melanotan II users. Until more people start to use melanotan-1 at more effective dosages it will probably remain prohibitively expensive for the average individual to use it. I think once people start to use melanotan-1 at the reported average effective doses there will likely be more interest in it.  
 
-Scott
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Re: no side effects?
Reply #9 - 12/22/08 at 16:35:55
 
Quote from Scott on 12/22/08 at 14:37:23:
Quote from Nargilyos on 12/22/08 at 11:54:54:
Thank you Scott.
So will it be unnecessary for me to try melanotan-1 with low doses (about 1-1.5 mg per day)? with my skin type- "1+" I don't know what noticeable results I will see. What is interesting is that nobody in the logs really did such a hige doses...
 I didn't think about melanotan-1 until I got some problems with melanotan II. Now I really don't know what to do...


I think once people start to use melanotan-1 at the reported average effective doses there will likely be more interest in it.

-Scott
yes. but with cost of about 165$ for 50mg melanotan-1. lets say that with the recommended it will finish after a week. and 165$ for a week is a lot more expensive then what the average person can spend. Its sad undecided I really interested in trail of melanotan-1...
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Re: no side effects?
Reply #10 - 12/22/08 at 19:32:55
 
If you are a strong responder you wont need that much. I took about 25mg across the summer and that was enough to stop me from burning and gain a bit more colour than without melanotan. I didn't go as dark as using around 30mgs of melanotan II, like I had in a previous summer, but it did the trick.
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While we continue to emphasize the safety of our drug formulation of afamelanotide [melanotan-1] in our all worldwide trials, I believe that the safety of this drug is as good as I have come across in 30 years in the field of drug development. - Dr Hank Agersborg - CSO of Clinuvel
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Re: no side effects?
Reply #11 - 12/22/08 at 20:03:05
 
Quote from ali on 12/22/08 at 19:32:55:
If you are a strong responder you wont need that much. I took about 25mg across the summer and that was enough to stop me from burning and gain a bit more colour than without melanotan. I didn't go as dark as using around 30mgs of melanotan II, like I had in a previous summer, but it did the trick.

 
This is probably true for people who get UV exposure at the same time as melanotan-1 dosing. The original study was to find the optimal dose for tanning with no uv exposure. The trick is going to be to experiment and find what one's personal dosing level vs. limited UV exposure is going to be.
 
-Scott
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Re: no side effects?
Reply #12 - 12/23/08 at 04:37:24
 
beach pimp, got my melanotan from Rogerhi
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Re: no side effects?
Reply #13 - 12/23/08 at 05:02:11
 
Thanks Scott for the replies.. I'm weighing in at 80kg, type 1 male, i simply can't afford 12mg per day, so in your opinion is it worth trying out 3mg per day? i've got plenty of melanotan-1 but can't be bothered jabbing myself everyday if there'll be no results.
 
please let me know what yuo think Scott
 
Cheers
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Re: no side effects?
Reply #14 - 12/23/08 at 05:05:50
 
Sorry, I really don't know because there just hasn't been as many forum members reporting on melanotan-1 usage as melanotan II. If I were you I would try it and start a melanotan-1 log about the experience and thereby help educate others about what taking comparatively smallish doses combined with UV exposure can do for someone of your skin type.
 
-Scott
 
 
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Re: no side effects?
Reply #15 - 12/23/08 at 06:12:04
 
This 2004 study of melanotan-1 combined with UV-B and/or sunlight (PDF) describes dosing at 0.08 mg/Kg per day as being effective but not as effective as the 0.16 mg/Kg per day dose level. It would appear that your level of tanning ability is going to be directly proportional to your dosage level. What that means is that while you will likely tan at the lower level you will have to go low and slow in your UV exposure so as to experience little or no UV skin damage.
 
-Scott
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Re: no side effects?
Reply #16 - 12/23/08 at 17:57:17
 
Well, Scott, according to the last Clinuvel trial 2008 Report of afamelanotide [melanotan-1], page number One:
( http://www.clinuvel.com/resources/pdf/annual_reports/2008/photoprotective.pdf )  
 
Dose per Kg is 0,02 mg / day.
 
16 mg implant in an aprox 10 days release means 1mg/day  ( 1 mg in a 24 hours release), it should be for a medium weight of 70 kg. = 0.02 mg/Kg/day .
BUT if we understand that a single daily  injection doesn´t means a constant release and the self life on the body is less than 2 hours the dose per injection is lower then than that.
 
At least this doses are tested safely for afamelanotide [melanotan-1] medical use, I dont know the result for tanning purposes, but I follow this doses (also lower) with moderate results during last summer
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Re: no side effects?
Reply #17 - 12/23/08 at 18:07:12
 
Quote from RIURAO on 12/23/08 at 17:57:17:
Well, Scott, according to the last Clinuvel trial ( http://www.clinuvel.com/resources/pdf/annual_reports/2008/photoprotective.pdf ), Dose per Kg is 0,02 mg / day.
16 mg implant in an aprox 10 days release means 1mg/day  ( 1 mg in a 24 hours release), it should be for a medium weight of 70 kg. = 0.02 mg/Kg/day .
BUT if we understand that a single daily  injection doesn´t means a constant release the dose per injection is lower then than that

Those quantities refers just to the implant of clinuvel or I will see result with 2-3 daily injections that suitable to it?
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Re: no side effects?
Reply #18 - 12/25/08 at 14:36:45
 
i am unsure if you can compare doses from an injection with doses from an implant as the implant is slow release
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Re: no side effects?
Reply #19 - 12/26/08 at 04:18:19
 
Quote from RIURAO on 12/23/08 at 17:57:17:
Well, Scott, according to the last Clinuvel trial 2008 Report of afamelanotide [melanotan-1], page number One:
( http://www.clinuvel.com/resources/pdf/annual_reports/2008/photoprotective.pdf )

Dose per Kg is 0,02 mg / day.

16 mg implant in an aprox 10 days release means 1mg/day  ( 1 mg in a 24 hours release), it should be for a medium weight of 70 kg. = 0.02 mg/Kg/day .
BUT if we understand that a single daily  injection doesn´t means a constant release and the self life on the body is less than 2 hours the dose per injection is lower then than that.

At least this doses are tested safely for afamelanotide [melanotan-1] medical use, I dont know the result for tanning purposes, but I follow this doses (also lower) with moderate results during last summer

 
This comparison is actually based upon your own personal experience and conjecture. I am actually citing 2 studies that address dosing via subcutaneous injections. Clinuvel's implant research demonstrated that there was essentially an order of magnitude (10) difference in dosing for implants vs. injections. As I said earlier, people are going to have to come up with their own personal dosing levels and regimens. They just need some landmarks to know what "average" dosages have been determined from research. Relative to the studies I've cited, total daily injection dosages can likely be reduced if folks get concurrent limited UV exposure and (likely) are willing to inject themselves multiple times per day as well.
-Scott
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