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Re: 100x better then Melanotan II (Read 2016 times)
Scott Stevenson
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Re: 100x better then Melanotan II
04/01/07 at 00:03:04
 
Quote from cbratton27 on 03/31/07 at 20:18:28:
People look at this arcticle that I found, they did testing and this new compound 1 is better in everything then melanotan II.

http://www.pharmcast.com/Patents/Yr2003/Jun2003/061703/6579968_Sexual061703.htm

The therapeutic window (the range from the desired therapeutic effect to observed adverse effects) for Compound 1 is on the order of >1,000-fold, compared to a 3- to 4-fold therapeutic window for melanotan II. That is, the optimal efficacious dose of melanotan II is approximately one-third to one-fourth the dose that causes observed adverse effects. For Compound 1, the optimal efficacious dose is less than one-one thousandth the dose that causes observed adverse effects. The significantly greater therapeutic window for Compound 1 demonstrates that it is better tolerated than Melanontan-II.

A primary advantage of the present invention is that it is efficacious at doses that do not cause deleterious side effects, such side effects including nausea, yawning, stretching, decreased appetite and other effects observed with melanotan II, or that causes decreased deleterious side effects as compared to melanotan II.

A second advantage of the present invention is that it provides compositions with a larger therapeutic window between desired therapeutic effects and the onset of undesired side effects than other melanocortin receptor-specific agents for the intended purpose.

Yet another advantage of the present invention is that it provides compositions with a greater safety margin between desired therapeutic effects and the onset of undesired side effects than other melanocortin receptor-specific agents for the intended purpose

Yet another advantage of the present invention is that it provides a peptide-based melanocortin receptor-specific pharmaceutical for use in treatment of sexual dysfunction which is efficacious at significantly lower doses than melanotan II or other melanocortin receptor-specific agents.

Yet another advantage of the present invention is that it provides a peptide-based melanocortin receptor-specific pharmaceutical for use in treatment of sexual dysfunction which is pharmaceutically active more rapidly following administration than melanotan II or other peptide-based melanocortin receptor-specific agents.

Yet another advantage of the present invention is that it provides a peptide-based melanocortin receptor-specific pharmaceutical for use in treatment of sexual dysfunction which, because of increased efficacy at low doses, may be administered by delivery systems other than art conventional intravenous, subcutaneous or intramuscular injection, including but not limited to nasal delivery systems and mucous membrane delivery systems.

These are the same folks who've been working on bremelanotide. What you've linked here is for sexual dysfunction.  
 
-Scott
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« Last Edit: 04/17/07 at 14:37:20 by Scott Stevenson »  

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RedBaron
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Re: 100x better then Melanotan II
Reply #1 - 04/01/07 at 01:57:32
 
Sounds good. Where to buy?  Smiley
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Kakarot
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Re: 100x better then Melanotan II
Reply #2 - 04/02/07 at 02:02:59
 
Hmm, interesting, but the big prob with melanotan II I think is that it works through the nitric oxide pathway which is inherently extremely growth promoting and dangerous, which is why so many get moles IMO.  Not sure how to stymie the aberrant growths exactly, but general immunity would be a good bet and possibly certain hormonal levels like thyroid and cortisol come to mind.
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Kakarot
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Re: 100x better then Melanotan II
Reply #3 - 04/02/07 at 02:11:45
 
also, would this stuff actually tan you?  Or is it only for ED?
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mullerizo
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Re: 100x better then Melanotan II
Reply #4 - 04/06/07 at 22:37:05
 
sorry this is off-topic but Kakarot does melanotan-1 work through this nitric oxide pathway also?
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