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Adzuki beans and melanin stimulation (Read 2052 times)
zorba990
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Adzuki beans and melanin stimulation
10/15/06 at 06:44:28
 
Someone on the LEF forum had posted this a while ago.
 
http://tinyurl.com/yarm7t
 
Hot-water extracts from adzuki beans (Vigna angularis) stimulate not only melanogenesis in cultured mouse B16 melanoma cells but also pigmentation of hair color in C3H mice.Itoh T, Furuichi Y.  
Imuraya Confectionary Co., Ltd., Mie, Japan. chuken@imuraya.co.jp
 
A hot-water extract of adzuki was obtained by boiling beans of adzuki (Vigna angularis). This hot-water extract was fractionated using HP-20 column chromatography. Its distilled water fraction (WEx) was found to stimulate tyrosinase activity in cultured mouse B16 melanoma cells and hair color pigmentation in C3H mice. At concentrations of 1-3 mg/ml, WEx stimulated melanogenesis without inhibiting cell growth. During this effect, WEx activated tyrosinase-inducing activity in the cells, but did not activate tyrosinase, which exists at an intracellular level. In this study, WEx increased cyclic adenosine-3',5'-monophospate (cAMP) content in the cells and protein kinase A (PKA) activity, and stimulated translocation of cytosolic protein kinase C (PKC) to the membrane-bound PKC. These results suggest that the addition of WEx activates the adenylcyclase and protein kinase pathways and, as a result, stimulates melanogenesis. WEx was found to have pigmentation activity on hair color in C3H mice. It might be useful in anti-graying, protecting human skin from irradiation.
 
PMID: 15914904 [PubMed - indexed for MEDLINE]
 

 
 
Update:  
Adzuki beans may inhibit the adhesion, invasion, and metastasis of melanoma cells!
 
http://tinyurl.com/yhsay7
 
 
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« Last Edit: 10/15/06 at 17:17:25 by zorba990 »  
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bmwballa
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Re: Adzuki beans and melanin stimulation
Reply #1 - 10/15/06 at 15:55:13
 
i see mice are very lucky, they have many ways to get tan without the sun lol
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zorba990
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Re: Adzuki beans and melanin stimulation
Reply #2 - 10/15/06 at 17:21:44
 
Quote from bmwballa   on 10/15/06 at 15:55:13:
i see mice are very lucky, they have many ways to get tan without the sun lol

 
LOL!  I see the next spa treatment:
"Adzuki bean soak: Soak in a luxurious tub of Adzuki beans and emerge with a golden tan!"
 
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zorba990
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Re: Adzuki beans and melanin stimulation
Reply #3 - 11/13/06 at 22:44:22
 
I am starting an experiment on the top of my
left foot with WEx (Adzuki).  Since it is effective
at lower concentrations and is also water soluble,
I'm hoping that it is less of a pain to deal with than
forskolin...
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Kakarot
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Re: Adzuki beans and melanin stimulation
Reply #4 - 11/14/06 at 00:09:04
 
Excellent, but how are you going to get a strong enough concentration?  What did they use in the study precisely?
 
Good luck, I think it's one of the better possibilities for sure.
 
Personally, I'm gonna consume large amounts of Astralagus, and am surprised no one has tried this yet as it doesn't have the high oral risks of forskolin and at a few studies show it increases melanin.
 
Also, it's good for immunity, and tanning is intimately involved with immunity. In fact, there are strong theories that tanning is all about body immunity actually.  
 
Anybody notice any difference in their immunity while on Melanotan?  Wouldn't be surprised if it was modulate at all.
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Kakarot
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Re: Adzuki beans and melanin stimulation
Reply #5 - 11/14/06 at 00:12:00
 
Zorba, I'll try this one with you.  But can you specify how you're making this adzuki extract?
 
I'm already trying a astralagus topical, a chaste tree topical, and may as well through this one on a skin patch too.
 
Also, would DMSO / phylogel be acceptable carriers?
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gidget
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Re: Adzuki beans and melanin stimulation
Reply #6 - 11/14/06 at 05:11:05
 
make sure to keep us up to date with your results! Sounds promising...
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envix
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Re: Adzuki beans and melanin stimulation
Reply #7 - 04/11/07 at 21:20:33
 
i tried this today. no change at all in skin or hair color. did anyone else get different results?
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