Photos 11-18-06
[img]http://melanotan.org/images/Socalguy/IMG_0001_1.JPG[/img

Hey all!
 
I found a patent using coleus family plants for pigmentation of skin and hair. They describe the carrier for an extract of coleus to enhance skin pigmentation before sun exposure.
 
Here's the composition:
Alcohol 42.5g
Propylene glycol 3g  
Menthol 0.05 g  
Hydroxypropyl methyl cellulose 1.5 g  
Extract of Coleus (dry weight) 0.03 g  
Perfumed aqueous excipients qsp 100 g <-- means to complete to 100g.
 
 
Here's the link:
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=2&am p;u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=74&f=G&l=50&co1=AND&d=PTXT&s1=forskolin&s2=melanin&OS=forskolin+AND+melanin&RS=forskolin+AND+melanin

Hey, me again!
 
There's also a face tanning gel and a Dermatological gel intended for promoting the pigmentation of the skin in this patent. And they bot use carbopol gel (which is easy to get and use).
 
And that makes me remember that the successive MelanX formulation was a gel (and that was confirmed to me by Dr. Fuller in person). But Cutanix at that time wanted a lotion to avoid skin dryness, and they were unable to design a good one (I mean as effective as the gel). So Fuller left Cutanix being bored of waiting.
 
Here's the recipe:  
 
Extract of Coleus 0.03 g  
Ethanol 30 g  
Distilled water 20 g  
Carbopol .RTM. gel qsp 100 g

Renaud, the dose for coleus seems really small, you sure that is correct?

Quote from renaud   on 11/20/06 at 00:07:44:

 
You've discussed this with Dr. Fuller personally?? Tell us more...!!

I find the situation with Dr. Fuller and MelanX very strange.  If he had a "miracle tanning product", I can't understand why he didn't get any other company to back him up once the issues with Cutanix didn't work out.
 
It's strange...why some miracle drug and its patent is basically sitting in someone's drawer.

Renaud, can you post the formula for MelanX please?
 
I can't figure out how to find it by searching US patent office.  Can you also specify how you do that and find all this excellent information?
 
Thanks.
 
I will try MelanX right away if I can take a look at it.

damn.  I did read about xanthines and melanocyte stimulation though, I remember.

BTW, I find strange that fat loss gels using Forskolin or Forskolin and xanthines combination don't show tanning effects. They use similar formulation as used in patents and the forskolin tanning solution used on mice. And they have to get through skin to fatty tissues. One of them would likely be a good tanner, since it's been proven to realy reduce fat (and it uses 2 cAMP stimulator). Here is its formulation:
 
Aqua, Ethyl alcohol cosmetic grade, Propylene glycol, Coleus forskohlii extract, Camellia sinensis extract, Methylal, Theophyllinum, Glycerin, Carbomer, Triethanolamine, Phenoxyethanol and mixt Paraben
Menthol, Imidazolidine urea
 
The links to the product:
 
http://www.beaute-test.com/force_ko_line_euromi.php
 
http://www.euromi.com/EUROMI_WEB/FR/forcekoline.htm

HOODLUM,
Good detective work and thanks for the cheers!
I wouldn't call it sudden success. I have PMLE and skin damage probably developed from all the sun exposure in my youth as a TYPE I. The final photo show all the red spots from the PMLE. It took about 2 weeks for the Pmle to go away with the daily application of a soothing lotion. When I was rubbing in the lotion I noticed that as I squeezed the capillary blood out of the skin the three forskolin threated areas indeed did have a faint tan. Today is three weeks since the last photo and 24 days since the last forskolin/UV and there is still a faint color to the treated areas. 23 days all the showers and lotion applications there is no way that it's just stain.  
I believe there was some tanning that took place, unfortunately my PMLE got in the way of a good outcome.
It did take a long time to get there, human skin being such a good barrier and propylene glycol a rather weak skin penetrater.
I bought soom 99.9% DMSO last Thursday, thinking I might try the experiment with it. I put 2 drops of DMSO on the underside of my forearm and rubbed it on with a latex glove- about the size of a silver dollar to test for any reaction. Within 3 minutes it was stinging, the skin became very red and actually rose up from the surrounding skin. It took about 24 hours for the reaction to go away- I won't be using DMSO anymore.
I am now in a trial with Melanobronze 16 days in now. I took before photos of my arm and will post before and after when completed.