Melanotan.org - Afamelanotide, Melanotan II and Bremelanotide Forums about tanning injections and tanning implants
See the Melanotan.org - afamelanotide introductory page.

Site Established: June 1999
Forum Established: January 2004

Greetings to you our Visitor. Please Sign In or Join.

05/19/13 at 07:19:58

Search the Melanotan.org forums:
Home Help Search Join

Big Change Coming to the Melanotan.org Forums (click here)

*PRE-MIXED MELANOTAN PEPTIDES MAKE PEOPLE SICK*
*DO NOT BUY MELANOTAN PEPTIDES ADULTERATED WITH A FILLER LIKE MANNITOL OR THAT ARE OUT OF DATE - DEMAND HIGH PURITY >99% AND FRESHNESS*

* Seen report(s) about the Melanotan peptides? Click here. *

*Please read - Governmental Health Agency Warnings*

*How is Melanotan.org Funded?*


Pages: 1 2 3 4 5 6 
Send Topic Print
Soclguy's trial with C. Forskolin (Read 47250 times)
mel-man
*Melanotanee*
*


Got Melanotan.org?

Posts: 9
Re: Soclguy's trial with C. Forskolin
Reply #60 - 11/05/06 at 07:16:37
 
Zorba,
 
Thanks for pointing that out .  That's even better that they work on 2 different pathways -  vitamin d increases cAMP in the skin and forskolin systemically.
 
Might be a potent combo in the right doses.  Based on the vitamin d and forskolin studies plus the anecdotal evidence from message boards, I might start this combo soon.  Current research is suggesting higher vitamin d supplemention for health and cancer prevention anyways.
Back to top
 
 
View Profile   IP Logged
mel-man
*Melanotanee*
*


Got Melanotan.org?

Posts: 9
Re: Soclguy's trial with C. Forskolin
Reply #61 - 11/05/06 at 07:32:25
 
Kakarot,
 
I think that there is no doubt that Dong Quai was working for aussiegirl since it contains Psoralen and bergapten which are photosensitizing.
 
Psoralens are used for viltiligo during PUVA treatment and bring on a strong tan even in fair skined.  The problem is that  psoralens are photocarcinogenic and mutagenic.  Big cancer risks.  doctors use oxsoralen and trisoralen today for PUVA treatments.  
 
The author John Griffin used psoralens to change himself into a black man. He wrote about his experiences in his book "black like me"
Back to top
 
 
View Profile   IP Logged
RichTan
-Melanotanophile-
***


Got Melanotan.org?

Posts: 171
Gender: male
Re: Soclguy's trial with C. Forskolin
Reply #62 - 11/05/06 at 16:06:48
 
Status update on next experiment with Forskolin:
I have applied a peel to my upper body.  I will repeat the peel in two weeks to prepare the skin.  I have contacted a vendor, who is trying to acquire 95%Forskolin.  Before my skin has finished peeling I should have the Forskolin to spot test for about 15 days.  If the 15 day test is sucessful I will try it on a wider area.  Suggestions are welcome.  I will post my results in the format sugested by darkhorse on the thread titled "Forskolin-Feedback from Experiments"
 
Temporarily I am using MSM,Lipoic Acid (on hyperpigment spots),Vitamin B12,Resveritol.  Except for the Vitamin(s) these will be discontinued for the Froskolin experiment.  Also, I will cut back on anti-oxidant food.
Back to top
 
« Last Edit: 11/05/06 at 16:23:53 by RichTan »  
View Profile   IP Logged
Kakarot
Supplier





Posts: 514
Gender: female
Re: Soclguy's trial with C. Forskolin
Reply #63 - 11/05/06 at 20:08:39
 
Quote from mel-man   on 11/05/06 at 07:32:25:
Kakarot,

I think that there is no doubt that Dong Quai was working for aussiegirl since it contains Psoralen and bergapten which are photosensitizing.

Psoralens are used for viltiligo during PUVA treatment and bring on a strong tan even in fair skined. The problem is that psoralens are photocarcinogenic and mutagenic. Big cancer risks. doctors use oxsoralen and trisoralen today for PUVA treatments.

The author John Griffin used psoralens to change himself into a black man. He wrote about his experiences in his book "black like me"

 
True, that is a problem.  Dong Quai is a psoralen.  So what I wonder is if Astralagus on its own can do anything in high oral doses -- which at least ostensibly would appear safe, even beneficial.  
 
Anybody planning on trying this?  
Back to top
 
 
Email View Profile   IP Logged
marialat796
-Melanotanophile-
***


Got Melanotan.org?

Posts: 106
Re: Soclguy's trial with C. Forskolin
Reply #64 - 11/08/06 at 04:29:58
 
I don't know if this is discussed in the scientific papers regarding Forskolin. I have the following question:
 
We all know that one of the most interesting aspects of Melanotan is its ability to convert the red melanin into the dark melanin (forget their names), reason why people who usually don't tan, or produce only the red melanin are able to tan once the Melanotan is in their system.
 
Now, from what I understood about Forskolin, is that it has tanning abilities because in a way it "tricks" the body into thinking that it has been exposed to UV, and reacts by producing a Tan without actually exposing the skin to the damaging rays.
 
My question is the following, will people who only produce the red melanin benefit from Foskolin? Does Forskolin help the body convert the red melanin into the dark melanin the same way Melanotan does? Because if not, I worry that by "tricking" the body into thinking it has been expose to UV, just cause Skin Type Is to produce red melanin only and not be able to eventually produce a Tan.
 
Sorry if this question is stupid.  I just wonder if this miracle herb helps produce dark melanin.
 
Thanks in advance, as always.
Back to top
 
 
View Profile   IP Logged
mel-man
*Melanotanee*
*


Got Melanotan.org?

Posts: 9
Re: Soclguy's trial with C. Forskolin
Reply #65 - 11/08/06 at 05:12:12
 
Maria,
 
If you do some google searching for "forskolin msh"  you will see that they both elevate cAMP.   MSH in the end actually tans by increasing cAMP.  
 
If you look at the article on the topical forskolin mice you will see that they mention "Mutations in the MSH receptor prevent the increase in cAMP levels".  This is why forskolin and msh work.  It is ultimately cAMP.
 
Don't get confused,  they are two different substances and effect more than just cAMP, so the side effects will be different.  This doesn't mean that forskolin will cause hyperpigmentation.   There are more mechanism (less important) involved in tanning also like tyrosinase, vitamin d, ACTH, dopa, ect.   Forskolin and MSH might effect these different also, thus creating different side effects.
 
So in theory they should both work the same for tanning.
Back to top
 
 
View Profile   IP Logged
Socalguy
-Melanotanner-
****


Got Melanotan.org?

Posts: 478
Gender: male
Re: Soclguy's trial with C. Forskolin
Reply #66 - 11/10/06 at 21:10:14
 
I am now approximately 45 days in the test. I did cut back to only one application per day on 10/25/06 after developing that PMLE breakout around the test area-which is now almost gone.
Today I started the sun exposure test.
1- Washed area well. not any more darker than a few weeks ago.
2- Photo. Cover half the test patches with a heavy masking tape & apply the lotion to the exposed area.
3- Cut 4 test holes in sock. The bottom hole is bare skin-no sunscreen.
4-11:30am PST. Southern California-warm- clear sky- bright sun. I exposed the area for 20 minutes. After the exposure I remove the tape and applied the lotion to the unexposed side in order to stay consistent. I will repeat for 4-6 days and post the final results.
Back to top
 
 
View Profile   IP Logged
Socalguy
-Melanotanner-
****


Got Melanotan.org?

Posts: 478
Gender: male
Re: Soclguy's trial with C. Forskolin
Reply #67 - 11/10/06 at 21:59:22
 
Nov, 10,'06
Here are the pictures. #1
Back to top
 
 
View Profile   IP Logged
Socalguy
-Melanotanner-
****


Got Melanotan.org?

Posts: 478
Gender: male
Re: Soclguy's trial with C. Forskolin
Reply #68 - 11/10/06 at 22:51:13
 
Sorry, I can't get the second picture to come up. The correct picture appears but when I click "post preview",it shows a different picture???
 
Figred it out. I had to delete the other photo since it was assigned the same picture number.
Back to top
 
« Last Edit: 11/11/06 at 00:34:30 by Socalguy »  
View Profile   IP Logged
Socalguy
-Melanotanner-
****


Got Melanotan.org?

Posts: 478
Gender: male
Re: Soclguy's trial with C. Forskolin
Reply #69 - 11/11/06 at 00:31:34
 
Pic#2
Back to top
 
 
View Profile   IP Logged
Socalguy
-Melanotanner-
****


Got Melanotan.org?

Posts: 478
Gender: male
Re: Soclguy's trial with C. Forskolin
Reply #70 - 11/11/06 at 00:42:40
 
RIchtan on your Post#63
What are you going to use to get the Forskolin in solution and into the skin? Thanks
Back to top
 
 
View Profile   IP Logged
RichTan
-Melanotanophile-
***


Got Melanotan.org?

Posts: 171
Gender: male
Re: Soclguy's trial with C. Forskolin
Reply #71 - 11/11/06 at 21:14:36
 
Same as you unless you have a suggestion.  
I think your experiment has been very well done.  It leaves us with unanswered questions. Among them are:  
1) Did some or all of the "tanning" come from staining?
2) Are there considerations to tanning larger areas?  
3) Why did the tanning reach a plateau after 15 days?  
 
I am presently prepping my skin to remove hyperpigmentation and other blemishes.  Peel, Lactic acid,laser to mention a few.  I also have sun damaged skin so my skin tends to have a lot of variation in color.  I plan to test with 95% forskolin (if I can afford it).  I have a vendor trying to locate it now.  The test should show if hyperpigmentation comes back as well as if white spots get tanned. I researched these white spots somewhat.  They are not normally perminant.  They are almost round and vary in size up to about the size of a quarter.  
 
This test should answer:
  1) Does forskoln produce hyperpigmentation?
  2) Does forskolin tan sun damaged skin?
  3) Does wide area application pose any special problems?
  4) Are forskolin impurities staining the skin?
Back to top
 
« Last Edit: 11/14/06 at 13:59:22 by RichTan »  
View Profile   IP Logged
RichTan
-Melanotanophile-
***


Got Melanotan.org?

Posts: 171
Gender: male
Re: Soclguy's trial with C. Forskolin
Reply #72 - 11/14/06 at 13:55:22
 
Socalguy:
I'm still waiting for 95% forskolin.  No results yet.
 
Has your "tan" deminished noticably yet?  
Even if it turns out to be a stain the results look better than sunless tanners!  
 
Back to top
 
 
View Profile   IP Logged
Kakarot
Supplier





Posts: 514
Gender: female
Re: Soclguy's trial with C. Forskolin
Reply #73 - 11/15/06 at 00:11:10
 
From the lit I keep reading, these cAMP elevating topicals like Forskolin and IBMX look like they'd need like at least a good month of application to kick in.  Human skin is fairly thick.
Back to top
 
 
Email View Profile   IP Logged
Socalguy
-Melanotanner-
****


Got Melanotan.org?

Posts: 478
Gender: male
Re: Soclguy's trial with C. Forskolin
Reply #74 - 11/15/06 at 00:15:20
 
RichTan,
Go back to my post #67. I keep increasing time of uv each day. I will report at the end of week, with photos and conclusions.
Back to top
 
 
View Profile   IP Logged
RichTan
-Melanotanophile-
***


Got Melanotan.org?

Posts: 171
Gender: male
Re: Soclguy's trial with C. Forskolin
Reply #75 - 11/17/06 at 15:08:56
 
My vendor is unable to supply 95% Forskolin. He writes:
"No, Forskolin is not normally made into a solid extract.  Tincture is easy
to find and I have been too busy to pull out the catalogs and go through
them.  I'll keep looking."
 
I now have to figure out if Tincture is a valid substitute.  Suggestions?
Back to top
 
 
View Profile   IP Logged
MSHie
Global Moderator
*****


Causality is
Irritating!

Posts: 1290
Gender: male
Re: Soclguy's trial with C. Forskolin
Reply #76 - 11/17/06 at 18:36:11
 
Hey Richtan, tincture is a generic word for colorant.  He may be saying that 95% Forskholin is easy to find, so look elsewhere.
Back to top
 
 
View Profile   IP Logged
WiseGuy
-Melanotanite-
**




Posts: 69
Gender: male
Re: Soclguy's trial with C. Forskolin
Reply #77 - 11/17/06 at 22:10:20
 
hey Socalguy,
 
 
hows the test been going lately?
Back to top
 
 



View Profile   IP Logged
Socalguy
-Melanotanner-
****


Got Melanotan.org?

Posts: 478
Gender: male
Re: Soclguy's trial with C. Forskolin
Reply #78 - 11/17/06 at 23:48:06
 
RichTan,
Medical Dictionary- "Tincture is an alcoholic or hydroalcoholic solution of an animal or vegetable drug or other chemical substance".
The forskolin I bought in capsule form was 20%, the filler was rich four. The ethanol is the solvent, it brings it into solution form- so I have made my own tincture. Then when I filter it, I filter out the rice flour. I found that about 8 caps in 10 ml of ethanol/propylene glycol probably produced a saturated solution- every molecule of ethanol was attached to a molecule of forskolin-so adding more forskolin would not make the solution any stronger.
I ground brown rice into flour and added it to some eth/prop
it did not go into solution, it just lay at the bottom of the vial
and did not change the color-the eth/pro remained clear. Therefore the color was not comming from the rice.
I will report my results with comments tomorrow
Back to top
 
 
View Profile   IP Logged
Socalguy
-Melanotanner-
****


Got Melanotan.org?

Posts: 478
Gender: male
Re: Soclguy's trial with C. Forskolin
Reply #79 - 11/18/06 at 20:03:17
 
My post #67 outlined my plan with sun exposure to the test areas. Since the sun is now in the southern hemisphere and getting weak here I tried to get exposure around noon.
11-10 20min. uv, 11-11 cloudy no uv, 11-12 30mins., 11-13 & 14 45mins., 11-15 & 16 50 mins.
The photo 2 days since I last applied forskolin and took last UV shows: I only got sunburned on the exposed skin and broke out with a PMLE reaction. So the forskolin did not protect my skin nor produce any significant darkening.
It's interesting that the lowest patch #1 untreated skin with no sunscreen, shows less sunburn than patches # 2,3,4 the treated skin. This leads me to believe that Forskolin may be a photosensitizer just like the Psoralens. I will take another photo in two days, hopefully the PMLE will have decreased and sunburn gone away enough to see if there is any darkening.
Since I never had a tan or used melanotan/melanotan II, I can't say if or how dark I could get. Human skin is thicker than mice.
1] I believe the propylene glycol is not an adequate transporter of the forskolin through the human skin.
2] I believe for the forskolin to work, it would need to be put into a liposome form to penetrate down to the dermis. I tried adding it to some liposome creams I had, but this did nothing not even stain the skin.
3] I think it needs to be chemically engineered into a liposome form by a chemical lab who specialize in this. Maybe Dr. Fisher's Co. will be able to develope this and hopefully the FDA won't have to get involved.
One person does not make a conclusive trial. Perhaps other type I & II's will try and report their results in detail. It may work in others. Even the cautious FDA approves all sorts of drugs that show results in only 50-60% of tests.
Those of you who can't get 98% ethanol, I found that 99% Isopropyl alcohol did take the forskolin into solution. I bought it off the shelf at Vons market- Safeway brand $2.00/pint. you can buy propylene glycol at a compounding pharmacy.
I may try a short trial using DMSO, a local herb store has it $13.50/8oz.
Back to top
 
 
View Profile   IP Logged
Pages: 1 2 3 4 5 6 
Send Topic Print