Socalguy
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Thanks KaKarot, Yes after I had this reaction, I found that Dr. Stanley Jacobs " The father of DMSO" ecommends 70%. It nevertheless scared me sufficiently to be very cautious. DMSO Penetrates Membranes and Eases Pain The first quality that struck Dr. Jacob about the drug was its ability to pass through membranes, an ability that has been verified by numerous subsequent researchers.1 DMSO's ability to do this varies proportionally with its strength--up to a 90 percent solution. From 70 percent to 90 percent has been found to be the most effective strength across the skin, and, oddly, performance drops with concentrations higher than 90 percent. Lower concentrations are sufficient to cross other membranes. Thus, 15 percent DMSO will easily penetrate the bladder.2 In addition, DMSO can carry other drugs with it across membranes. It is more successful ferrying some drugs, such as morphine sulfate, penicillin, steroids, and cortisone, than others, such as insulin. What it will carry depends on the molecular weight, shape, and electrochemistry of the molecules. This property would enable DMSO to act as a new drug delivery system that would lower the risk of infection occurring whenever skin is penetrated. DMSO perhaps has been used most widely as a topical analgesic, in a 70 percent DMSO, 30 percent water solution. Laboratory studies suggest that DMSO cuts pain by blocking peripheral nerve C fibers.3 Several clinical trials have demonstrated its effectiveness,4,5 although in one trial, no benefit was found.6 Burns, cuts, and sprains have been treated with DMSO. Relief is reported to be almost immediate, lasting up to 6 hours. A number of sports teams and Olympic athletes have used DMSO, although some have since moved on to other treatment modalities. When administration ceases, so do the effects of the drug. Dr. Jacob said at a hearing of the U.S. Senate Subcommittee on Health in 1980, "DMSO is one of the few agents in which effectiveness can be demonstrated before the eyes of the observers....If we have patients appear before the Committee with edematous sprained ankles, the application of DMSO would be followed by objective diminution of swelling within an hour. No other therapeutic modality will do this." Chronic pain patients often have to apply the substance for 6 weeks before a change occurs, but many report relief to a degree they had not been able to obtain from any other source.
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