I ordered the nasal spray bremelanotide (PT-141) from IBE about a week ago.  It arrived very promptly, 2 days after I placed the order, by express mail.  
 
It arrived in an expressmail pouch, and within that pouch there was a cardboard box.  The bremelanotide (PT-141) bottle was wrapped in bubble wrap inside the box, and alongside it was a cold pack.  The cold pack was at room temperature by the time it arrived.  This was a very odd and poor way to package it, IMO.  The bubble wrap essentially insulated the bottle from the cold pack, keeping it warmer.  If the bubble pack had instead been wrapped around both the cold pack and the bottle, placing them together, it would have insulated the cold pack and kept the bottle nice and cold, and this method would not cost any more.
 
In any case one or two days at room temp should not seriously degrade a peptide product like this, so I went ahead and tried it.  The first trial was four sprays, just to establish safety and side effects.  I got a pretty good facial flushing from this within a few minutes, which lasted about an hour.  So something was active in the spray.  No other effects were seen - no nausea, no change to erectile capability, etc.  However with four sprays this was to be expected as they currently recommend 12.
 
A day later I tried the full 12 sprays.  Interestingly there was less facial flsuhing than on the first trial.  No other effects were seen at any time on this trial as well - no change in erectile capability, no other side effects, etc.
 
I believe the problem here is probably NOT degradation in shipping.  I am familiar with a number of peptide products, indcluding other nasal spray peptides (e.g. Stimate), and a couple days of room temperature exposure is not enough to degrade them to this degree.  It is far more likely that either a) IBE has not in fact synthesized Bremelanotide, or b) the nasal spray formulation contains ingredients that are immediately degrading the peptide into byproducts.  Various commonly used nasal spray formulation preservatives, for example, could cause this.
 
I'll try it one more time at 12 sprays, but at that point the bottle will be almost used up, so that is going to be the last experiment, probably.
 
IBE will need to test and evaluate the nasal spray forumlation after mixing and letting it stand for some time, to test stability.  I beleive they will find that they need to re-formulate.

I did not say it had to be related to formulation.  I postulated that was one possibility (the "b" possibility), withthe "a" possibility being that they have not correctly synthesized or otherwise obtained Bremelanotide.  Given your experiment with the sterile powder, it is now quite a bit more likely that they do not have Bremelanotide.

I looks like IBE changed their email addy - it is now listed as admin@innovative-research.net on pages where they have an email link.  That address works.
 
They have written me to say they are looking into the issue with their supplier.  They are going to try sending me the sterile powder plus a nasal sprayer kit that I can reconstitute the powder with on the spot, to make sure it isn't a degradation of the nasal spray formulation during storage or shipping.  That seems like a worthwhile thing to try.

Well IBE never did send me a sprayer kit.  They haven't answered any of my emails either.  It appears they have gone silent and aren't going to follow though with bremelanotide (PT-141) product.  Maybe they found out their supplier was supplying bogus material.

Rich,
 
That sounds cool enough to me...
 
Only trouble is, they will keep it COOL when transporting it! Not wrapped in insulating plastic like last time.
 
At least they gave me a total refund on the bogus spray... so I'll still give them some credit. Keeping my fingers crossed.
 
Any ideas when this new stuff will become available?
 
Maria