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WARNINGS / FAQ Section / New Peptide Users Read! (Read 58138 times)
Scott Stevenson
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WARNINGS / FAQ Section / New Peptide Users Read!
11/11/08 at 19:25:42
 
WARNINGS / FAQ For New Peptide Users - Please Read before posting questions  
This material is not authorized for reproduction elsewhere by any means without express permission from Melanotan.org.
 
At no point in time will anything in Melanotan.org FAQs or forums override licensed medical practitioner to patient directives regarding matters of health. Direct doctor to patient counsels/advice ALWAYS takes precedence. Melanotan.org is not to be considered a legitimate source for direct medical advice. No individual is authorized to give direct medical advice on Melanotan.org. For direct medical matters always seek the assistance of licensed and qualified medical practitioners, NEVER rely upon Melanotan.org for such matters.
 
These WARNING / FAQ posts have been formulated both from information found in published clinical trials of the melanotan peptides and also from anecdotal reports.
 
Individuals considering using either of the as of yet unlicensed and unregulated melanotan peptides should know that there can be serious risks to one's health in doing so.
 
Be aware of Governmental Health Agency Warnings specific to the melanotan peptides  
against their usage outside of regulated clinical trials
.
 
Before reading this FAQ please review the entirety of the first post of this thread.
 
 
 
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HEALTH CONCERNS - SEEK MEDICAL ASSISTANCE
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If a health concern should present itself during a regimen do not automatically assume it stems from some aspect of the regimen. Instead, do not hesitate to be medically examined by a licensed health care practitioner. Be as upfront with the practitioner about your regimen as possible and know that generally speaking the more information doctors have the better they will be in a position to help you.
 
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SEEING DERMATOLOGISTS
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 Section summary: It is strongly recommended to have one's skin examined by a dermatologist to check for any skin issues prior to starting usage of a melanotan peptide. This is also true if any skin issue should become apparent while using a melanotan peptide or after finishing a regimen.
 
Because usage of the melanotan peptides by people is a relatively new phenomenon (ie: the first human clinical trial of melanotan-1 was in 1991), it is advisable to visit a dermatologist to have a skin "check up" (physical) particularly for those who've never been able to tan previously. Request that the dermatologist do a thorough examination of your skin to check for any irregularities (ie: differences in skin tone, latent yeast/fungal infections, moles, etc.) Discuss with the dermatologist what are the aspects of skin tanning that individuals in general should be aware of in terms of how one's skin can be affected (besides becoming tan). Be aware that when developing a natural tan (natural - meaning based on melanin - and particularly for those who've never had a tan before) it is possible (for a relatively small population of individuals affected by various skin disorders) that certain areas of skin ("white spots"/patches) will not be able to tan and conversely certain areas may remain tanned ("brown spots"/patches) after completely ceasing a tanning regimen. There are many known causes (most of which are of an infectious <ie: yeast/fungal> nature) for these types of spots/patches and ordinarily this type of thing is not something that affected pale individuals in particular will become aware of until they can achieve a tan.  If one is diagnosed with a dermal yeast infection (like tinea versicolor) they will generally be prescribed very effective and simple to use medicines (ie: Nizoral) for treatment. This is why it is a good idea to consult with a dermatologist to see if there are any issues that you may not be aware of. Additionally, you may want to see what information the dermatologist can share with you (if any) about the melanotan peptides. Such a checkup (ie: in the guise of a, "skin cancer screening") may be covered by your country's national healthcare system or your private/company healthcare plan in which case there will be either no charge for you or simply a small fee.  
 
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MOLES & FRECKLES
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 Section summary: Those with any moles (especially on the face) and/or freckles should know that they will almost certainly darken* and that additional not particularly visible moles will likely become more noticeable when tanning especially while using a melanotan peptide (initially), if such darkening will bother you then Melanotan.org strongly advises either not starting use of a melanotan peptide or having such moles and/or freckles removed and skin completely healed prior to starting a usage regimen.
 
Those with a prevalence of moles and/or prominent freckles should be aware that any sort of tanning of one's skin can affect them and in particular when tanning with the usage of the melanotan peptides (darkening - particularly moles). Indeed, previously latent (not noticeable) moles can become visible / more visible when one starts to tan (regardless of using the peptides or not). Moles and freckles are concentration points for melanin and accordingly they will very likely be the first places to accumulate melanin prior to other areas of the skin (which for some people at least in the initial stages of using one of the peptides can set up a disagreeable contrast - particularly if not slowly building up a tan with lower than normal doses of peptide*). It may be advisable to undergo simple and safe mole and/or freckle removal treatments with a well qualified dermatologist prior to starting any melanin tanning regimen.  A good example of the appearance enhancing benefits of having moles removed can be found in the following log where a forum member underwent Radio Surgitron and Intense pulsed light mole removal treatments in correspondence with a desire to have a natural looking tan. These types of treatments may be covered by your healthcare plan (best to inquire). If scarring is likely to occur, do not have moles removed or undergo other potentially scar causing procedures while using a melanotan peptide see the "SCAR FORMATION" section below.
 
It is not currently definitively known how long it can take for melanotan peptide darkened moles to fade. The cosmetic ramifications of mole darkening and a progression of fading or not is an aspect of melanotan peptide usage about which no scientific studies are known to have been published.  
 
*: There has been some speculation in the forums that at certain dosing levels (at least initially) and progression speed of tanning moles can darken disproportionately fast relative to surrounding skin and this is what has caused issues for folks who've experienced this. Correspondingly with this speculation there is a debate that if a person builds up their tan slower than normal with lower than normal dosing that such a disproportionate contrast will not occur and instead a more natural and even tanning across the skin (including moles/freckles) will happen. Another view is that this initial difference in contrast is unavoidable.
 
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UV EXPOSURE
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 Section summary: For fair skinned peptide users limited UV exposure is likely necessary and helps both darker skinned and fair skinned individuals have a more natural looking tan. Never overexpose oneself to UV light. UV light overexposure is known to cause skin damage (particularly cumulatively) that can lead to skin cancers. Get only enough UV exposure to effectively tan and not more (start with low levels for short amounts of time).
 
While the administration of Melanotan peptides via injections has been clinically demonstrated to make it possible for people who ordinarily cannot tan or have difficulty doing so (type I/II individuals) to be able to as well as make it easier for type III and IVs to do so (even with no UV exposure) they will generally not be most effective and the resulting skin tones will not look most natural without some limited exposure to UV light (ie: sunlight).  
 
Real sunlight is the best, but sunbeds work too.  
The amount of UV exposure necessary to achieve good results differs for EVERY person.  
Some people will see their skin darken after only one sunbed session, while it will take a few sessions for others.  
 
Usage of melanotan-1 has been clinically demonstrated to reduce UV skin damage (not completely prevent it). While Melanotan II hasn't been clinically demonstrated to do this, because it allows one to tan in the same way, it is quite likely that this damage reduction effect is also found with its usage. Because UV light overexposure can negatively impact and damage skin it is best to limit exposure to a level that is just effective enough in producing a tanning effect but not more. Optimally (particularly when starting out) not more than 5 minutes in one session per day. Do not overexpose your skin to UV light, the melanotan peptides weren't designed to make skin capable of tolerating UV overexposure. Regardless of peptide usage, overexposure will damage your skin. Please know that UV skin damage is cumulative meaning that damage will build up over time. Cumulative damage has been shown to correlate with subsequent development of skin cancers and while scientists hypothesize that using the melanotan peptides can have a protective effect against skin cancers this has yet to be clinically demonstrated. Please note that melanin converts UV light into heat, as one becomes darker the skin will become noticeably warmer in the presence of the same tanning level of UV light as prior to being darker. This is a good sign and means that the increased level of melanin is providing additional photoprotection.
 
In clinical trials on melanotan-1 it was reported that areas of the skin that have been more chronically exposed to UV light (ie: face, back of the neck, arms, and hands) were found to respond more readily to the melanogenesis (melanin producing) effects of the peptide. This effect has been reported in logs on the site as well (for melanotan II usage). For proper tanning balance it is advisable that early in getting UV exposure to develop a melanotan peptide tan one uses a strong SPF sunblock (30+ SPF) or towels to cover areas most subject to daily UV exposure (ie: the face, back of the neck) to allow other less chronically sun exposed areas to tan first and then subsequently expose the face (and other areas) for less time (or as needed) to UV light to thereby achieve a well balanced tan.  
 
When exposing oneself to UV light it is imperative to wear proper eye protection. Eyes are very sensitive to UV light and can be damaged irreparably from chronic and/or overexposure. If using sunbeds do not simply "scrunch up" your eyes during exposure but wear proper UV blocking protective eyewear (this is usually supplied by a salon). This cannot be emphasized enough.
 
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TAN DURATION
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 Section summary: Melanotan peptide plus UV exposure based tans are known to take months to completely fade (generally longer than a non-melanotan peptide based tan). Be prepared for a long fading period after stopping peptide plus UV exposure tanning.
 
Be advised that unlike solely a-MSH (our body's naturally inherent tanning hormone) based tans, on average Melanotan peptide based tans that have been "activated" with UV exposure can last for months before skin returns completely to pre-tan levels of paleness. The precise amount of time will vary depending upon a number of factors relative to a given individual's system (ie: what level of darkening was achieved) and which peptide was used but generally speaking one should not consider starting on a melanotan peptide +UV exposure tanning regimen unless one is prepared to have a tan that will not completely fade for at least 2 to 3 months (there have been anecdotal reports in the forums of both shorter and longer times for peptide users).  
For those seeking to increase the rate of tan fading it is advisable to completely avoid UV exposure (stay out of sunlight and avoid other UV sources) and concurrently use high SPF sunscreens regularly that are both UVA and UVB blocking on light exposed areas  (simple UVB blocker types will help also but not as much as UVA+UVB).  
 
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SCAR FORMATION COSMETIC ISSUES
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 Section summary: Avoid any procedure and/or events that could lead to scarring in the weeks/months prior to or while using a melanotan peptide. Scars formed concurrently while skin undergoes changes in pigmentation (ie: tan formation) occur can become permanently discolored. Wait for any forming scars to completely heal and form and do not start or use a melanotan peptide during this period.
 
The formation of relatively significant hypertrophic type scars (ie: keloids) are known to become discolored when the wound and the skin surrounding the wound concurrently undergo changes in pigmentation (ie: melanogenesis - tan formation). In an article on "scar revision" the United States' National Institutes of Health (NIH) counsels those who undergo such a procedure to, "Avoid exposure to the sun for several months after treatment. Use sunblock or a dressing (such as a Band-Aid) to keep the sun from permanently tanning the healing scar." in the recovery section of the page. The reason for this counsel is to prevent the scar from becoming impregnated with melanin stemming from the body's melanogenesis process. While actively using the melanotan peptides melanogenesis occurs regardless of UV exposure (as shown by the 1991 clinical study). What this means is that if one begins to form a scar while taking one of the melanotan peptides it is possible that the scar will become discolored relative to the rest of the skin surrounding it. When hypertrophic type scars are forming it is very advisable for cosmetic reasons to not use a melanotan peptide. Those planning on undergoing potentially scar forming procedures/surgery should not begin using a melanotan peptide and those using a peptide should stop doing so as much time in advance as possible. Once scar formation starts it is best to abide the NIH's advice and wait until a scar has completely healed and finished forming before undergoing any melanogenesis processes (don't use a melanotan peptide). Depending upon the severity of the scar(s) this can take up to several months.
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« Last Edit: 08/03/10 at 23:57:18 by Scott Stevenson »  

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Re: FAQ Section / New Users Please Read
Reply #1 - 03/10/06 at 04:37:58
 
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SOURCING A MELANOTAN PEPTIDE
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 Section summary: Only use pharmaceutical grade high purity (99%+) melanotan peptides preferentially sold in vacuum sealed vials. Independent testing of what one purchases allows for the highest confidence that what one has bought is what it was sold as.
 
As of 2010 the melanotan peptides are not approved for human usage by any governmental regulatory health agencies outside of human trials (for melanotan-1), as a result there are no government recognized/regulated sources for either melanotan peptide for human usage purposes. If one is going to experiment with a melanotan peptide it is imperative that one uses pharmaceutical grade (GMP) high purity peptide (99% and higher purity) preferentially sold in vacuum sealed vials. Never purchase or use peptides from a source that cannot guarantee that what they are selling is pharmaceutical grade (meaning fit for human usage) regardless of whether or not they are sold for human usage or not and preferably buy peptide sold in vacuum sealed vials. Avoid unprofessional sellers like the plague, this is your health/life on the line. There are very real health dangers of using peptides that are either made at a substandard purity level, contaminated / adulterated / putrified (gone bad), or something completely else (counterfeit) other than a melanotan peptide. Avoid sellers offering the peptides in "premix" form. Premixed melanotan peptides are going to be degraded by the time they are delivered. Such degraded peptide will cause allergies and/or general sickness (especially over time). It is unprofessional for a supplier to even offer premixed peptide and again, unprofessional suppliers should be avoided at all costs.
 
For extra safety melanotan.org recommends that buyers have their peptides independently tested for purity. Such independent testing will allow for the highest degree of confidence that what one has purchased is indeed a high purity melanotan peptide. Avoid peptides that are sold with any fillers (ie: mannitol) added to them as such fillers can drastically alter the way the body will react to a given dosage of peptide. Be skeptical about any forum connected with a given seller, chances are the forum will not fully reflect an independent view of what people's experiences are with what that supplier is selling and/or the peptides in general.
 
Why is purity so important?
 
One of the primary reasons that purity is so important is that over time one can develop an allergy to non-melanotan peptide substances found in vials and subsequently not be able to use such vials having such impurities (even in very small quantities). This is also true for peptide that is not kept fresh. Over time peptides will begin to decay due to oxidation and/or natural bacterial processes if not stored properly (much like food left out or left for a long time in a refrigerator). This is why it is helpful to purchase peptides sold in vacuum sealed vials.  
 
Why are vacuum sealed vials preferred and how does one know if a vial is under vacuum?
 
Vacuum sealed vials are preferred because the vacuum helps prevent oxidation and bacterial decay of the peptide itself. Without a seal oxidation will begin to make the peptide convert into something that is not a melanotan peptide and bacteria are able enter into a given vial (via air contamination) and cause a given vial of peptide to begin to spontaneously decay. Also, any miniscule quantities of bacteria that might have been introduced into a given vial during manufacturing have a much better chance to multiply in a non-vacuum sealed vial.
 
When injecting bacteriostatic water into a vial the vacuum will draw the water into the vial slightly. If the water in the syringe is not drawn into the vial (after initial piercing) then it's a sure bet that the vial either was never vacuum sealed or lost it's vacuum.  
 
Where can I get peptides tested?
 
A company called M-Scan Inc. has been used in the forums by members. Their website is found here:
 
http://www.m-scan.com/
 
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DOSING AMOUNT GUIDELINES
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Find your weight on the chart below. 10mg is the average amount of one cycle. About 3 cycles are needed for the "loading phase." For someone of average weight (140-175), around 30mg is needed. This amount will vary from person to person. Heavier people, and skin type 1's need more than lighter people and those with higher skin types.
 
-----
10 mg / 12.00 injections = 0.833 mg  ---   42 kg =  92 lbs   @0.02mg/kg  
 10 mg / 11.50 injections = 0.870 mg  ---   43 kg =  96 lbs   @0.02mg/kg  
10 mg / 11.00 injections = 0.909 mg  ---   45 kg = 100 lbs   @0.02mg/kg  
 10 mg / 10.50 injections = 0.952 mg  ---   48 kg = 105 lbs   @0.02mg/kg  
10 mg / 10.00 injections = 1.000 mg  ---   50 kg = 110 lbs   @0.02mg/kg  
 10 mg /  9.50 injections = 1.053 mg  ---   53 kg = 116 lbs   @0.02mg/kg  
10 mg /  9.00 injections = 1.111 mg  ---   55 kg = 122 lbs   @0.02mg/kg  
 10 mg /  8.50 injections = 1.176 mg  ---   59 kg = 130 lbs   @0.02mg/kg  
10 mg /  8.00 injections = 1.250 mg  ---   63 kg = 138 lbs   @0.02mg/kg  
 10 mg /  7.50 injections = 1.333 mg  ---   67 kg = 147 lbs   @0.02mg/kg  
10 mg /  7.00 injections = 1.429 mg  ---   71 kg = 157 lbs   @0.02mg/kg  
 10 mg /  6.75 injections = 1.481 mg  ---   74 kg = 163 lbs   @0.02mg/kg  
10 mg /  6.50 injections = 1.538 mg  ---   77 kg = 170 lbs   @0.02mg/kg  
10 mg /  6.25 injections = 1.600 mg  ---   80 kg = 176 lbs   @0.02mg/kg  
10 mg /  6.00 injections = 1.667 mg  ---   83 kg = 184 lbs   @0.02mg/kg  
 10 mg /  5.75 injections = 1.739 mg  ---   87 kg = 192 lbs   @0.02mg/kg  
10 mg /  5.50 injections = 1.818 mg  ---   91 kg = 200 lbs   @0.02mg/kg  
10 mg /  5.25 injections = 1.905 mg  ---   95 kg = 210 lbs   @0.02mg/kg  
10 mg /  5.00 injections = 2.000 mg  ---  100 kg = 220 lbs   @0.02mg/kg  
 10 mg /  4.75 injections = 2.105 mg  ---  105 kg = 232 lbs   @0.02mg/kg  
10 mg /  4.50 injections = 2.222 mg  ---  111 kg = 245 lbs   @0.02mg/kg  
10 mg /  4.25 injections = 2.353 mg  ---  118 kg = 259 lbs   @0.02mg/kg  
10 mg /  4.00 injections = 2.500 mg  ---  125 kg = 276 lbs   @0.02mg/kg  
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For example, someone weighing 184 lbs should be taking a dose of 1.66667mg daily. They will be able to get this amount out of the vial 6 times ( 10 / 1.66667 = 6)
 
Many people have began to emulate the slow-release method by giving themselves multiple injections daily. For example, that 184 lb. person would take 2 injections (1 morning / 1 night) of about .8333mg.
 
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SYRINGES (NEEDLES / PINS)
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Any insulin syringe will work. These are usually disposable and come in 10 packs. BD is a great brand. Buy something that is 28,29, or 30 guage. The higher the gauge, the smaller the opening at the end of the needle. That means the higher the gauge, the less pain incurred. 28,29,30 guage. 1/2 inch needle. 1cc, 1/2cc, or 1/3cc will work.
 
Individuals planning on commencing a peptide regimen will need approximately 50 individually hermetically sealed/packaged, sterile syringes (DO NOT USE syringes that come unpackaged) for one month of usage with everyday dosing (30 for each day and ~ 20 for mixing purposes and as a margin for error).
 
DO NOT REUSE DISPOSABLE SYRINGES, doing so is dangerous and can have serious health consequences (ie: bacterial infection and abscess formation).
 
DO NOT SHARE SYRINGES, doing so is dangerous and will lead to the spread of infections (ie: blood borne viruses) found in any one of the individuals sharing a needle (ie: HIV-AIDS, Hepatitis C, etc.).
 
DO NOT USE OUT OF DATE SYRINGES, syringes have an expiration date which is marked on the side of the box they are sold in. Use only in date (non-expired) syringes. Using out-of-date syringes will very likely make you sick.

 
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RECONSTITUTION
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Melanotan peptides come in powder form. They cannot be injected in powder form, so they have to be mixed with a dilutant. The best dilutant is in date (not expired) bacteriostatic water. DO NOT USE water that is beyond its expiration date. Such water can be ordered typically inexpensively online. NEVER USE TAP WATER AS IT IS UNSAFE AND WILL LEAD TO BACTERIAL INFECTIONS OR OTHER COMPLICATIONS ARISING FROM OTHER CONTAMINANTS. Use only in date MEDICAL GRADE water sold specifically for injection purposes.
 
When you reconstitute, take your syringe and stick it into the vial holding bac. water. Turn it upside down, and draw out the desired amount. This is usually between 1/2cc and 1cc.
If you have 1/2cc syringes, draw out liquid up to the 50 mark on the syringe. This will fill up the whole syringe, since the markings only go up to 50.
 
Now, look on the chart and find out how many injections you can get from the 10mg vial. From the above example, we are using a 184 lb. person. This person gets 6 injections from the 10mg vial. Therefore, draw out 50 units of bac water and shoot it into the vial. Repeat this 5 more times.  
 
6 injections ->  
1)Draw out 50 from bac. water, shoot into melanotan II vial
2)Draw out 50 from bac. water, shoot into melanotan II vial
3)Draw out 50 from bac. water, shoot into melanotan II vial
4)Draw out 50 from bac. water, shoot into melanotan II vial
5)Draw out 50 from bac. water, shoot into melanotan II vial
6)Draw out 50 from bac. water, shoot into melanotan II vial
 
You now have 300 units of bac. water in your melanotan II vial. Roll it on a hard surface for a while, until the melanotan II dissolves. (do not shake)
 
If you are going with 1 injection per day, every time you are ready to inject, draw out 50 units.
 
If you are going with 2 injections per day, every time you are going to inject, draw out 25 units.
 
Here is what an image of 10 mg of melanotan II reconstituted with 1 cc of bacteriostatic water will look like:
 

 
Note that the bacteriostatic aqueous solution is colorless and clear (not milky/cloudy).
 
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INJECTIONS
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See the Subcutaneous injection FAQ.
The preferred method is a sub-cutaneous injection into the fat above the abdomen.
 
If you are not familiar with how to inject, watch this video:
Real player:  
http://www.pharmacy.unc.edu/carelabs/Real_Files/movies/subqtape.ram  
 
AVI (windows media player):  
http://www.pharmacy.unc.edu/carelabs/AVI_Files/subqtape.avi  
 
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STORAGE
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Melanotan II in powder form - freezer
Reconstituted melanotan II - refrigerator
 
The melanotan II in the freezer will last for many months without degrading.
 
The reconstituted melanotan II will begin to degrade around 2 weeks in the fridge.  
 
An alternative to keeping reconstituted vials in the fridge is preloading syringes. If you plan to get 6 injections out of your vial, then draw your dose into all 6 syringes at the same time. Place them in the freezer. When you are ready to inject, take one out, let it sit at room temp for 5 minutes (to thaw), then inject.
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« Last Edit: 03/20/10 at 15:32:59 by Scott Stevenson »  
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Re: FAQ Section / New Users Please Read
Reply #2 - 03/10/06 at 17:29:07
 
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