melanotan.org

Publishing information about the Melanotan peptides since June 14, 1999.
Updated: Monday August 29, 2011
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Melanotan-1 ([Nle4, D-Phe7]α-MSH - under its generic name "afamelanotide") was approved on May 5, 2010 by the Italian Medicines Agency (AIFA - Agenzia Italiana del Farmaco) as a medication for those afflicted with the orphan disease erythropoietic protoporphyria (EPP). The drug is used to induce photoprotective dermal eumelanin pigmentation and thereby reduce the effects of painful, burning dermal photosensitivity caused by the disease. 1 2 This marks the first time ever that a governmental health regulatory agency has given approval for this drug for usage in human medicinal therapy. For EPP treatment the drug will be marketed under the trade name "Scenesse"® a registered brand name trademark of Clinuvel Pharmaceuticals Ltd. (formerly EpiTan Ltd. 3 4).

Note: The website Melanotan.org and its operators do not sell and have never sold either of the two melanotan peptides or related products.
We do, however, provide 100% donor supported international forums for adults
where legal purchase, importation, possession and usage have been and are discussed.
An Aug. 29, 2011 Australian News report about the
melanotan-1 "afamelanotide" bioabsorbable subcutaneous implant
(as mentioned in the video, it is not about melanotan II).
Note: Melanotan.org is in no way affiliated with the Australian company
Clinuvel Pharmaceuticals Ltd. developing the implant mentioned in this video.

A related January 29, 2009 Wired Science article can be found here: Suntan Drug Greenlighted for Trials 		Melanotan-1 "afamelanotide": Tan Without the Sun
A September 8, 2004 Ivanhoe Broadcast News Production:
From: HealthCentral.com



Jan. 22, 2009 Australian "Today Tonight" article related to this News
Note: The researchers in the image (from left to right) are Dermatologist Dr. Norman Levine,
Endocrinologist Dr. Mac E. Hadley (1930-2006 - 1 2), and Pharmacologist Dr. Robert T. Dorr.
What are the drugs Melanotan-1 and Melanotan II?

Based upon a quote of the Arizona Cancer Center found at sunless.com (on June 14th, 1999):

Melanotan-1 and Melanotan II are both synthetic versions of α- melanocyte stimulating hormone that were created, synthesized and developed at The University of Arizona and the Arizona Cancer Center. Melanotan-1 is a linear, full length peptide (containing all 13 amino acids). Melanotan II is a shortened, circular version of melanotan-1. Both Melanotan-1 and Melanotan II develop dermal pigmentation without sun exposure but because Melanotan II had libido enhancement and spontaneous erections as side effects, it is now being developed as a sexual and erectile dysfunction drug.

To be particularly clear regarding Melanotan-1 (due to previous incorrect news reports) it should be noted that it does not cause sexual arousal nor have erectile effects. These aspects are only found in the drugs Melanotan II and bremelanotide.
Who created them?

The Arizona Cancer Center located at The University of Arizona.



Melanotan.org Discussion Areas
Find discussions centered on the powder forms of these
peptides as well as the latest News/Info regarding
Melanotan-1 (afamelanotide, Scenesse®), Melanotan II
and bremelanotide in our forums.

Where can I find more information about Melanotan-1 and Melanotan II?

General Information

Looking for the company that is developing Melanotan-1?

Try Clinuvel the company in Australia that is developing it.


Clinuvel Pharmaceuticals Limited is a sub-licencee of Melanotan-1 from: Competitive Technologies
(Who originally licensed it from MelanoTan Corporation.)

Looking for the company that was developing a derivative of Melanotan II for erectile
dysfunction (ED) and female sexual dysfunction (FSD)?
Try http://www.palatin.com/ the company in New Jersey, USA that is now developing it for hemorrhagic shock.
Unfortunately for those looking on their site for the latest information concerning Melanotan II will find it mentioned only in the listing of publications regarding bremelanotide. This has greatly limited the ease with which interested parties can directly locate them via web searches relative to the term Melanotan II. Due to changes they've made to the Melanotan II peptide, they use the much less obvious name "bremelanotide". When surfing their site look for bremelanotide or pt-141 .

Palatin Technologies originally was a sub-licencee of Melanotan II from: Competitive Technologies. This original sub-license is no longer valid.


Melanotan.org Discussion Areas
Find discussions centered on the powder forms of these
peptides as well as the latest News/Info regarding
Melanotan-1 (afamelanotide, Scenesse®), Melanotan II
and bremelanotide in our forums.

Publications about the Melanotan peptides

United States Patent Application for Melanocortin receptor agonists by Merck and Co (mentioning Melanotan)

Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II.
Wessells H, Levine N, Hadley ME, Dorr R, Hruby V.

Increased eumelanin expression and tanning is induced by a superpotent melanotropin [Nle4-D-Phe7]-alpha-MSH in humans.
Dorr RT, Dvorakova K, Brooks C, Lines R, Levine N, Schram K, Miketova P, Hruby V, Alberts DS.

Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study.
Wessells H, Fuciarelli K, Hansen J, Hadley ME, Hruby VJ, Dorr R, Levine N

Skin pigmentation and pharmacokinetics of melanotan-I in humans.
Ugwu SO, Blanchard J, Dorr RT, Levine N, Brooks C, Hadley ME, Aickin M, Hruby VJ.

Controlled-release delivery system for the alpha-MSH analog melanotan-I using poloxamer 407.
Bhardwaj R, Blanchard J.

Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.
Dorr RT, Lines R, Levine N, Brooks C, Xiang L, Hruby VJ, Hadley ME.

Search the word Melanotan at the National Library of Medicine's PubMed site.

Melanotan-II Studied For Impotence of Psychological Origin Melanotan-II, a synthetic compound that influences skin pigmentation, has been shown to stimulate erections in men whose impotence has a psychological basis. (Journal of Urology 1998;160:389-393)

Dorr RT, Lines RR, Levine N, Brooks C, Xiang L, Hruby VJ, Hadley ME: Evaluation of Melanotan-II, A Superpotent Cyclic Melanotropic Peptide in a Pilot Phase-I Clinical Study, Life Sciences, Vol.58, No 20:1777-1784, 1996

N. Surendran, S.O. Uguw, L.D. Nguyen, E.J. Sterling, .T. Dorr and J. Blanchard, "Absorption Enhancement of Melanotan-I: Comparison of the Caco-2 and Rat In-Situ Models", Drug Delivery, 2, 49-55 (1995).

N. Surendran, L.D. Nguyen, A.R. Giuliano, and J. Blanchard, "Mechanisms of Acylcarnitine-mediated Enhancement of Calcium Transport in the Caco-2 Monolayer Model", J. PHarm. Sci., 84, 269-274 (1995).

N. Surendran, S.O. Ugwu, E.J. Sterling, and J. Blanchard, "High-performance Liquid Chromatographic Assay for Melanotan-1 in Biological Matrices", J. Chromatogr., 670, 235-242 (1995).

E.-L. Lan, S.O. Ugwu, J. Blanchard, X. Fang, V.J. Hruby and S. Sharma, "Preformulation Studies with Melanotan-II: A Potential Skin Cancer Chemopreventive Peptide", J. Pharm. Sci., 83, 1081-1084 (1994).

There are individuals who have experimented and are experimenting with these peptides individually. Melanotan.org discussion areas cover some of their experiments and experiences. Please note however that any experimentations done with these peptides are the sole responsibility of each individual practicing his or her own experiments and the operators/owners of Melanotan.org will not be held responsible for any and all use of information gathered from our sites in formulating said experiments.
USE INFORMATION CONTAINED IN THE DICUSSION AREAS AT YOUR OWN RISK.

This site in in no way affiliated with either Competitive Technologies, Palatin Technologies, or Clinuvel Pharmaceuticals Limited
or any of the sites linked to from this site.All linked to sites are solely responsible for the information they provide.
For questions concerning this site either utilize our discussion areas or send email
to the address found for the registrant of the domain Melanotan.com.



"SCENESSE" is a registered trademark of Clinuvel Pharmaceuticals Ltd.
The Melanotan.org site and forums are not sponsored, endorsed or otherwise affiliated with Clinuvel Pharmaceuticals Ltd.

*** made on a MacBook Pro 17" *** khujgid7x5